For a model set of 31 different building morphologies in an urban setting, road traffic noise exposure has been calculated and analysed. For five of the building morphologies also vegetation surfaces on facades and roofs were studied. Facade exposures were analysed for both smaller (single-sided) flats and larger (floor-through) flats, considering the direct exposure from the roads as well as the non-direct exposure at noise-shielded positions like inner yards, applying a noise mapping software in combination with a prediction model for the non-direct exposure. Using noise indicators Lden and Lnight, the disease burden, in terms of DALY (Disability-Adjusted Life Years) per person, was estimated and analysed, via predictions of annoyance and sleep disturbance. The resulting effects of varying the building morphology and adding vegetation are shown and discussed, including effects of a bonus model for flats having additional facade elements with lower noise exposure.