In real active noise control system implementation, the arrangement of secondary sources and error microphones have significant effect on the performance of the system. Analytical and experimental ways are usually combined to determine the best system layout. In this paper, we use COSMOL Multiphysics to accurately model the acoustic environment in enclosures with the real measured dimensions and parameters. Matlab is adopted to simulate the basic active noise control algorithms. The combined simulation results are used to decide the optimal system layout of the real ANC system. Experiments are conducted on a real ANC system with EVAL-21489-EZLITE from ADI to validate the analyzed and simulation results.