In this study an integrated virtual thermal-acoustic manikin design used inside ventilated and occupied office spaces is developed and applicated. The component of the virtual thermal manikin evaluates the internal airflow and occupants thermal, thermo-physiology and clothing systems and calculates the thermal comfort and the indoor air quality levels. The component of the virtual binaural manikin evaluates the direct and indirect sound and calculates the reverberation time. The space geometry with complex topology is developed using a Computer Aid Design (CAD), while the occupants geometry is made using geometric equations. The grid generation, in the surrounding space surfaces and around the external occupants surfaces geometry, is used to calculate the radiative heat exchanges and the sound propagation. In this study, performed in an office room occupied by eight persons and equipped with personalized ventilation system, the thermal comfort level, the air quality level and the space reverberation time is evaluated and discussed. In accordance with the obtained results the values are, in general, in accordance the actual standards.