The change in the self-reported health status of residents associated with the reduced aircraft noise around Tan Son Nhat airport (TSN) after the epidemic outbreak in early 2020 was investigated in three stages. Stage 1 is pre-outbreak when the airport was operating at its highest capacity. Phases 2 and 3 are three months and six months after the stop of international flight operation implemented in March 2020. Data on the residents health status was obtained from face-to-face interviews. The questionnaire items were composed of Noise annoyance questions using the 11-point ICBEN scale, the Total Health Index, Health and lifestyle questionnaire, Depression Scale revised questionnaire, and questionnaires to identify insomnia, hypertension, and hearing loss. Other factors related to living conditions such as education, income, or housing were also collected as health adjustment factors. The noise levels of phases 2 and 3 were estimated by updating the noise contour map of phase 1 using the TSN airports operation data in corresponding periods in 2020. This study provided evidence relating to variation of the residents health status due to the noise situation change.